Ninaveli - Aesthetics Manufacturer

Ninaveli PN Pro

Overview

A highly purified 2% Polynucleotide (PN) product with Lidocaine, with very low protein and endotoxin levels. KFDA Approved

Product Characteristics

20mg/ml Polynucleotides
2% Polynucleotides (PN)
2ml Syringe
KFDA Approved

The Future of Advanced Skincare: Polynucleotides (PN) Beyond Traditional Hydration

The landscape of premium skincare is experiencing a profound shift towards advanced, skin-mimicking nourishment. At the forefront of this cosmetic evolution are Polynucleotides (PN). Derived from highly purified, rigorously filtered DNA fractions of Salmon, PNs act as exceptional skin conditioners. When applied, these powerful complexes provide a profound surge of moisture and vitality, reinforcing the skin's natural barrier and promoting a visibly firmer, plumper, and more resilient-looking complexion.

The Ultimate "Glass Skin" Trend

This advanced conditioning mechanism is exactly why Polynucleotides have become the most sought-after ingredient in modern beauty. Today's consumers demand a natural, lit-from-within radiance—a flawless finish that looks inherently healthy rather than artificially altered. PNs deliver the ultimate cosmetic support, intensely hydrating the skin to visibly smooth the appearance of fine lines, refine uneven texture, and restore a brilliant, energized glow to tired or weathered-looking skin.

Pioneered by South Korean Salmon DNA Innovation

This global trend owes its incredible momentum directly to the advanced skincare laboratories of South Korea. Long recognized as the epicenter of beauty innovation and the creators of the coveted "glass skin" ideal, South Korea pioneered the widespread use of highly purified Polynucleotides. Backed by advanced extraction technologies that ensure unparalleled purity and cosmetic efficacy, South Korean formulators have set a new worldwide benchmark, making topical PNs an indispensable pillar in any premium aesthetic routine.

Our product range includes the below main active ingredients

Active Ingredients

Polynucleotides (PN)

PN is a highly advanced, deeply nourishing ingredient that supports the skin's natural vitality. This potent concentration helps to visibly improve skin texture and elasticity, promoting a firmer, more supple, and rejuvenated appearance. It is the ultimate secret to achieving a plump, youthful-looking "glass skin" glow.

Salmon DNA

Advanced topical nourishment for a visibly firmer, flawlessly luminous complexion.

Indications

"The ultimate cosmetic solution to quench, smooth, and visibly redensify tired-looking skin."

Severe Surface Dehydration

Instantly quenches dry, depleted skin, restoring a visibly plump and dewy appearance (especially ideal for the PN + HA blends).

Visible Loss of Firmness

Supports the skin's structural feeling, enhancing natural bounce, elasticity, and suppleness.

Fine Lines and Wrinkles

Softens the appearance of superficial expression lines and minimizes the look of skin creping.

Dullness and Lackluster Tone

Revives a tired, stressed complexion to achieve that coveted, brilliant "glass skin" radiance.

Uneven Skin Texture

Smooths and refines the look of rough or uneven surface texture for a flawlessly silky finish.

Environmental Skin Fatigue

Acts as a daily cosmetic defense to visibly refresh and energize skin subjected to harsh environmental stressors.

Benefits & Effects

"The ultimate cosmetic power to visibly plump, smooth, and illuminate your complexion."

Benefits	Effects
Delivers profound, long-lasting moisture to the skin's surface layers	Visibly plumps the skin to soften the appearance of fine lines and surface wrinkles
Enhances the skin's natural feeling of structural bounce, resilience, and elasticity	Imparts an immediate, coveted "glass-like" luminous glow
Provides advanced cosmetic nourishment to visibly support and condition the skin barrier	Noticeably smooths and refines uneven or rough surface texture
Revitalizes the overall look of tired, stressed, and environmentally weathered skin	Reduces the look of dry, crepey skin for a flawlessly silky, supple finish
Acts as a premium daily defense against visible dullness and dehydration	Restores a fresh, energized, and visibly youthful radiance from the very first application

Clinical Studies

Below are several published clinical studies that were performed on the active ingredients stated below.

Ingredient: Polynucleotides

Study Title: A Real-Life Assessment of Injectable Polynucleotides High Purification Technology in Aesthetic Medicine for Skin Rejuvenation

Summary: This extensive observational study evaluated the cosmetic performance of highly purified Polynucleotides on the face, neck, and décolleté. The clinical data demonstrated that PN application significantly enhanced the skin's visible moisture retention, feeling of elasticity, and overall surface quality. Over 93% of targeted cases showed moderate to significant improvements in refining the appearance of skin roughness and fine lines, resulting in a noticeably revitalized, youthful-looking complexion.

Reference: Eliana L, Anna P, Stefania B, Concetta S, Luisa C, Agnieszka D, Andrea B, Laura B, Carolina P, Simone S. A Real-Life Assessment of Injectable Polynucleotides High Purification Technology in Aesthetic Medicine for Skin Rejuvenation. J Cosmet Dermatol. 2026 Jan;25(1):e70532.

Understanding the Clinical Results (GAIS): The Global Aesthetic Improvement Scale (GAIS) charts visually represent the professional clinical grading of the skin's appearance post-treatment compared to its initial baseline. The GAIS Results FACE chart illustrates that 100% of observed patients experienced a visible enhancement in facial skin quality, with over 53% achieving "marked" or "excellent" cosmetic improvements such as profound hydration and a visibly smoother surface texture. Similarly, the GAIS Results Neck chart demonstrates the formula's targeted effectiveness on notoriously delicate tissue, proving that over 93% of cases experienced moderate to significant visible improvements in the neck area, including a noticeble reduction in surface creping and an enhanced feeling of natural elasticity. Together, these charts provide quantifiable clinical proof of the complex's exceptional revitalizing power.

Ingredient: Polynucleotides and Hyaluronic Acid

Study Title: The Effect of Polynucleotide-Hyaluronic Acid Hydrogel in the Recovery After Mechanical Skin Barrier Disruption

Summary: This study specifically explored the synergistic cosmetic effects of combining Polynucleotides (PN) with Hyaluronic Acid (HA). The clinical findings proved that the PN+HA complex acts as an exceptional conditioning agent for the skin. It significantly reduced trans-epidermal water loss (TEWL) and profoundly fortified the skin's natural moisture barrier, leaving the skin visibly calmer, smoother, and intensely hydrated.

Reference: Ha YJ, Tak KH, Jung JM, Lee JL, Kim CW, Ah YC, Kim SS, Moon IJ, Yoon YS. Skin Res Technol. 2024 Sep;30(9):e70068.

The above in this study provides compelling visual proof of the formula's ability to lock in moisture and support the skin's surface barrier. The graphs track Trans-Epidermal Water Loss (TEWL) and the rate of barrier recovery over a 72-hour period following mechanical disruption of the skin. They clearly demonstrate that the application of the Polynucleotide and Hyaluronic Acid (PN+HA) complex significantly halts water loss and accelerates moisture barrier recovery compared to untreated skin. This serves as undeniable scientific evidence that the complex acts as an exceptional hydrating shield, instantly quenching depleted skin and restoring a healthy, resilient, and deeply conditioned surface.

Ingredient: Polynucleotides and Hyaluronic Acid

Study Title: Clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross-linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study

Summary: This split-face clinical trial demonstrated the profound aesthetic benefits of Polynucleotides in targeted facial zones. The application of PN provided excellent viscoelastic support to the skin's surface. Participants experienced a significantly smoother and plumper appearance, with the Polynucleotides beautifully enhancing the skin's natural feeling of firmness while softening the look of deep surface creping.

Reference: Araco A, Araco F, Raichi M. J Cosmet Dermatol. 2023 Jan;22(1):146-155.

Understanding the Clinical Results (Figure 2): This chart visually proves how effectively the Polynucleotide (PN) and Hyaluronic Acid (HA) combination visibly smooths the appearance of deep smile lines (nasolabial folds) over a six-month period. At the 6-week mark (T1), the side of the face receiving the pure PN formula showed a noticeable cosmetic improvement in the skin's surface compared to the untreated side. By the 3- and 6-month marks (T2 and T3), after HA was added to complement the PN, the skin appeared significantly plumper, firmer, and more refined. The red text on the chart simply highlights that these visible smoothing effects were scientifically proven to be a true, lasting enhancement compared to the skin's original condition at baseline.

Further Information

Packaging & Storage

Packaging Configuration

Volume: 2ml Pre-Filled Sterile Syringe Asset

This product configuration is intended strictly for single-use application only.

Temperature Control

Store all unopened products in a cool, dry environment between 2°C and 25°C (35°F to 77°F). Protect the formulations from extreme heat and ensure they are never frozen.

Light Protection

Polynucleotides and Hyaluronic Acid are sensitive to prolonged UV and light exposure. Keep the vials and syringes securely within their original outer packaging when not in immediate use to shield them from direct sunlight and ambient clinical lighting.

Strict Single-Use Protocol

Immediate Use: Once the protective seal is broken or the syringe is unsealed, the formulation must be utilized immediately or discarded.

Disposal Guidelines: Under no circumstances should opened vials or syringes be stored, refrigerated, or reused for subsequent treatments. Any remaining product and all empty packaging must be safely and appropriately discarded.