Ninaveli - Aesthetics Manufacturer

Ninaveli HI-LO

Overview

A highly effective skin booster consisting of dual weight H-HA and L-HA with Polynucleotides

Product Characteristics

70mg high molecular weight Hyaluronic Acid
10mg low molecular weight Hyaluronic Acid
0.5% Polynucleotides
2.5ml Syringe

Introducing Ninaveli HI-LO: Advanced Dual-Action Bio-Remodeling

Ninaveli HI-LO represents the next generation of intense tissue remodeling and multi-depth skin revitalization. Housed in a generous 2.5ml syringe, this premium formulation boasts an extraordinary total concentration of 80mg of pure Hyaluronic Acid (HA) and 0.5% Polynucleotides (PH). By offering one of the most robust HA concentrations available to practitioners, Ninaveli HI-LO serves as a highly effective tool to aggressively combat skin laxity, restore foundational moisture, and deliver a profound, natural-looking lift to depleted and aging tissue.

Simultaneously, the high molecular weight HA creates a supportive, moisture-binding matrix closer to the surface, effectively acting as an invisible scaffolding. This synergistic "HI-LO" complex effectively remodels the dermal structure, tightening the skin and smoothing fine lines from the inside out.

Beyond its remarkable aesthetic performance, Ninaveli HI-LO is engineered with absolute safety and strict regulatory compliance at its core. It is fully registered with both the CPNP (European Union) and SCPN (United Kingdom), ensuring it flawlessly meets the most rigorous international safety and quality standards. Furthermore, the product has been dermatologically tested.

The secret to its exceptional clinical efficacy lies in its meticulously engineered dual-molecular architecture. The formula features an optimized blend of 70mg of High Molecular Weight HA alongside 10mg of Low Molecular Weight HA. The low molecular weight molecules penetrate deeply into the dermis to intensely hydrate and stimulate cellular activity at the foundational level. The 0.5% PN provides a good maintanance dose.

Our product range includes the below main active ingredients

Active Ingredients

Hyaluronic Acid (HA)

The gold standard in topical hydration, Hyaluronic Acid acts as a profound moisture magnet for the skin. It instantly quenches surface dehydration, binding essential water to the skin to visibly plump the complexion, smooth uneven texture, and deliver that coveted, dewy "glass skin" radiance.

Polynucleotides (PN)

PN is a highly advanced, deeply nourishing ingredient that supports the skin's natural vitality. This potent concentration helps to visibly improve skin texture and elasticity, promoting a firmer, more supple, and rejuvenated appearance. It is the ultimate secret to achieving a plump, youthful-looking "glass skin" glow.

Indications

"Advanced topical hydration designed to visibly plump, smooth, and revitalize the complexion."

Intense Surface Hydration

Applied topically to flood the epidermis with multi-depth moisture and reinforce the skin's natural protective barrier.

Visible Skin Plumping

Delivers a high concentration of hyaluronic acid to visually enhance surface firmness, bounce, and elasticity.

Texture & Tone Refinement

Effectively smooths the appearance of fine lines and uneven surface texture for a remarkably supple complexion.

Radiance Restoration

Revitalizes dull, fatigued skin by locking in essential moisture for a lasting, healthy, and luminous glow.

Benefits & Effects

"Harnessing dual-molecular technology for unparalleled surface moisture, enhanced barrier defense, and a visibly plumper complexion."

Benefits	Effects
Dual-Weight Synergy: Blends high and low molecular weight hyaluronic acid to deliver comprehensive, multi-depth surface hydration.	Multi-Level Moisture: Instantly quenches the skin by drawing and locking vital hydration across the epidermal layers.
Generous Application: The 2.5ml syringe provides an ample volume of premium serum for thorough, full-face professional cosmetic treatments.	Surface Plumping: Visibly fills superficial fine lines and textural irregularities for a noticeably smoother, bouncier complexion.
Rigorous Safety Profile: Dermatologically tested to ensure exceptional skin compatibility, safety, and predictable performance.	Barrier Defense: Creates an invisible, breathable moisture shield on the skin's surface to prevent daily trans-epidermal water loss.
Certified Quality: Fully CPNP and SCPN registered, guaranteeing strict adherence to premier European and UK cosmetic standards.	Revitalized Glow: Erases signs of fatigue and dullness by restoring a dewy, radiant, and healthy luminosity to the face.

Clinical Studies

Below are several published clinical studies that were performed on the active ingredients stated below.

Ingredient: Hyaluronic Acid - dual weight

Study Title: Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment

Summary: This clinical trial strongly validates the dual-weight approach used in Ninaveli HI-LO. The study demonstrates that applying different molecular weights of HA topically yields superior cosmetic results compared to a single weight. High molecular weight HA forms an excellent, breathable film on the skin's surface to prevent moisture loss, while low molecular weight HA effectively penetrates the stratum corneum (the outermost layer of the epidermis) to provide deep, sustained hydration and visibly improve skin elasticity and texture.

Reference: Pavicic T, Gauglitz GG, Lersch P, Schwach-Abdellaoui K, Malle B, Korting HC, Farwick M. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. J Drugs Dermatol. 2011 Sep;10(9):990-1000.

FIGURE 2. The affects of topical HA formulations containing A) 50, B) 130, C) 300, D) 800 and E) 2000 kDa HA, respectively, on skin hydration (reported as percentage of variation in companion to a placebo-treated area).

Ingredient: Hyaluronic Acid

Study Title: Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects

Summary: Evaluating extensive clinical data, this study focuses on the purely cosmetic and surface-level benefits of HA applications. The findings illustrate that highly concentrated topical HA treatments act as an exceptional non-invasive anti-aging tool. Regular application successfully reinforces the epidermal barrier, visibly plumps superficial fine lines, and promotes a significantly smoother, more refined skin topography without the need for dermal penetration.

Reference: Bukhari SNA, Roswandi NL, Waqas M, Habib H, Hussain F, Khan S, Sohail M, Ramli NA, Thu HE, Hussain Z. Int J Biol Macromol. 2018 Dec;120(Pt B):1682-1695.

Ingredient: Hyaluronic Acid

Study Title: Hyaluronic acid: A key molecule in skin aging

Summary: This comprehensive dermatological review highlights HA as the primary molecule responsible for skin hydration. The research confirms that the cosmetic application of HA profoundly enhances the skin's moisture-binding capacity. By continuously drawing water to the skin's surface, topical HA maintains an optimal hydration environment, which is clinically proven to reduce the visible signs of skin fatigue, combat dryness, and restore a supple, youthful luminosity to the complexion.

Reference: Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012 Jul 1;4(3):253-8.

Further Information

Packaging & Storage

Packaging Configuration

Volume: 2.5ml Pre-Filled Sterile Syringe Asset

This product configuration is intended strictly for single-use application only.

Temperature Control

Store the pre-filled syringes in a cool, dry environment, ideally between 2°C and 25°C. Strictly avoid freezing or exposing the product to extreme heat, as temperature fluctuations can degrade the integrity of the hyaluronic acid gel.

Light Protection

Premium hyaluronic acid formulations are sensitive to prolonged UV exposure. Keep the syringes securely inside their original outer cartons when not in use to protect them from direct sunlight and harsh ambient lighting.

Maintain Integrity

Do not open the protective blister pack or remove the syringe cap until immediately prior to the application to guarantee absolute product purity and safety.

Strictly Single-Use

Once the syringe is opened, the product must be used immediately during the treatment session. To maintain strict hygiene and safety standards, any remaining product must be safely discarded and never stored or reused for subsequent applications.